FITC标记的酸盐耐药蛋白ARS2抗体
产品名称： FITC标记的酸盐耐药蛋白ARS2抗体
英文名称： Anti-ARS2/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ARS2/FITC Conjugated antibody
FITC标记的酸盐耐药蛋白ARS2抗体
| 英文名称 | Anti-ARS2/FITC |
| 中文名称 | FITC标记的酸盐耐药蛋白ARS2抗体 |
| 别 名 | ARS2 protein; Arsenate resistance protein ARS2; Arsenite resistance protein 2; Arsenite resistance protein; ASR2; MGC126427; Serrate; Serrate RNA effector molecule homolog (Arabidopsis); Serrate RNA effector molecule homolog; SRRT; SRRT_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 101kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ARS2 (721-760aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ARS2(Arsenite resistance protein 2) confers arsenite resistance. The protein belongs to the ARS2 family. Arsenic is a human carcinogen whose mechanism of action is unknown. The arsenite acts as a comutagen by interfering with DNA repair. Two genes, ASR1(Arsenite resistance protein 1) and ASR2 (Arsenite resistance protein 2), confer arsenite resistance to arsenite-sensitive cells. ASR1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitin like region fused to S30 ribosomal protein. Arsenite inhibits ubiquitin dependent proteolysis. The tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite. Subunit: Interacts with NCBP1 and DROSHA. Interacts with CASP8AP2 and ERBB4. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the ARS2 family. Database links: UniProtKB/Swiss-Prot: Q9BXP5.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
AsS2（亚酸抗性蛋白2）赋予亚酸抗性。该蛋白属于ARS2家族。是一种人体致癌物质，其作用机制尚不清楚。亚酸通过干扰DNA修复而起到协同作用。两个基因AsR1（亚酸抗性蛋白1）和AsR2（亚酸抗性蛋白2）赋予亚酸对亚酸敏感细胞的抗性。ASR1与大鼠FAU基因几乎完全同源，肿瘤抑制基因含有与S30核糖体蛋白融合的泛素样区。亚酸盐抑制泛素依赖的蛋白水解。肿瘤抑制基因FAU基因产物或泛素系统的某些其它方面可能是毒性的靶标，泛素系统的破坏可能有助于亚酸盐的遗传毒性和致癌性。