he Human Gastric Cancer qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in human stomach tumor DNA. Gastric cancer, or stomach cancer, originates in any part of the stomach, but can spread to other organs such as the esophagus, liver, lungs, and lymph nodes. Improving the very poor prognosis of this disease requires identifying early molecular markers, and progress has been made in identifying acquired copy number alterations (CNA) in key oncogenic pathways. During oncogenesis, large percentages of gastric tumors acquire insertions and deletions in genes that regulate epithelial cell and fibroblast proliferation and differentiation, as well as signaling pathways such as WNT. Genes were chosen from the most frequently amplified or deleted genes relevant to oncogenic pathways and gastric cancer biology based on the primary literature and public databases. This array may serve as a useful tool to help classify gastric cancer samples by genotype and help verify gastric cancer phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available

胃癌qBiomarker拷贝数PCR芯片用于研究已报道的与人类胃癌有关且发生频繁突变的23个基因的拷贝数。许多基因的拷贝数变异都会导致先天性异常胃癌起源于胃的任何部分,但可以扩散到其他器官如食道、肝、肺和淋巴结。改善这种疾病很差的预后,需要识别早期的分子标记,以及在关键致癌途径中识别获得拷贝数突变(CNA)的进程。在肿瘤形成过程中,大比例的胃肿瘤捕获插入和删除的基因，这些基因调节上皮细胞和成纤维细胞增殖和分化，以及WNT等信号通

基因选择自主要文献和公共数据库中致癌途径和胃癌生物学基础上扩增或缺失的相关基因。这个芯片可助于胃癌样本的基因型分类并验证胃癌症表型生物标记。这个芯片可以使每个基因在每个样本中有四个重复，同时包含一个稳定的多拷贝参考实验，通过适当的DNA插入标准化精确检测拷贝数。简单的产品模式和操作程序让任何一个具备实时定量PCR仪的实验室都可进行常规可靠的拷贝数检测。

qBiomarker拷贝数PCR芯片用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。

提供96孔板，384 -(4×96)板，和100 孔。

Cell Cycle: FBXW7.

Channels & Transporters: ATP7B.

Chaperone Activity: BAG2.

Cytoskeleton: CTNNB1, FAM84B, IQGAP1.

ECM & Cell Adhesion: ADAM23, CD44, CEACAM6.

Epigenetics: MED1.

G-Protein Signaling: DOCK8, IQGAP1.

Growth Factors: SFRP1, WNT2.

Hedgehog Signaling: MTSS1, RAB23.

Metabolic Enzymes: AOAH, GLO1, MTAP.

Receptor Tyrosine Kinases: ERBB3.

Transcription Factors: FOXO1,

ZFHX3.

Ubiquitin Ligase: FBXW7.

Others: LRRC4C, PPP1R1B