PIBF1,孕酮诱导阻断因子1抗体

产品编号HZ-9612R
英文名称PIBF1
中文名称孕酮诱导阻断因子1抗体
别 名PIBF 1; PIBF; PIBF1; PIBF-1; Progesterone immunomodulatory binding factor 1; Progesterone induced blocking factor 1; Progesterone-Induced Blocking Factor 1; RP11 505F3.1; PIBF1_HUMAN; C13orf24.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
PIBF1,孕酮诱导阻断因子1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量90kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PIBF1/C13orf24
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PIBF1,孕酮诱导阻断因子1抗体PubMedPubMed
产品介绍background:
PIBF is synthesized during pregnancy in response to progesterone by progesterone receptor-positive T lymphocytes (mostly gamma-delta T cells). In the presence of PIBF, natural killer (NK) cells inhibit the release of perforin from storage granules and therefore fail to lyse target cells. In humans, the amount of cells that express PIBF is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF is associated with the nucleus, whereas secretion of shorter forms is induced by activation of the cell. Research suggests that PIBF functions as a transcription factor in its full-length form, while smaller forms may act as cytokines. The PIBF gene encodes a deduced hydrophilic 757-amino acid alpha-helical protein with an N-terminal signal sequence, a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an endoplasmic reticulum membrane retention signal, and many presumeed N-glycosylation and phosphorylation sites.

Function:
Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.

Tissue Specificity:
Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon.

Gene ID:
10464

Database links:
Entrez Gene: 10464 Human
Entrez Gene: 52023 Mouse
Omim: 607532 Human
SwissProt: Q8WXW3 Human
Unigene: 441926 Human

PIBF1,孕酮诱导阻断因子1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.