CCR6,细胞表面趋化因子受体6抗体

产品编号HZ-1542R
英文名称CCR6
中文名称细胞表面趋化因子受体6抗体
别 名CKR6; C-C chemokine receptor type 6; BN 1; BN1; C C chemokine receptor type 6; C C CKR 6; CC chemokine receptor type 6; CC CKR 6; CC R6; CCCKR6; CCR 6; CD 196; CD196; CD196 antigen; Chemokine (C C motif) receptor 6; Chemokine (C C) receptor 6; Chemokine (CC motif) receptor 6; Chemokine (CC) receptor 6; Chemokine receptor 6; Chemokine receptor like 3; CKR 6; CKR L3; CKRL3; CMKBR 6; CMKBR6; DCR 2; DCR2; DRY 6; DRY6; G protein coupled receptor 29; GPR 29; GPR CY4; GPR29; GPRCY 4; GPRCY4; LARC receptor; Seven transmembrane receptor lymphocyte 22; STRL 22; STRL22; CCR6_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 信号转导 转录调节因子 细胞表面分子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
CCR6,细胞表面趋化因子受体6抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CCR6 (151-241aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CCR6,细胞表面趋化因子受体6抗体PubMedPubMed
产品介绍background:
CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. It is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP 3 alpha). This receptor has been shown to be important for B lineage maturation and antigen driven B cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells.

Function:
Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Gene ID:
1235

CCR6,细胞表面趋化因子受体6抗体Database links:
Entrez Gene: 1235 Human
Entrez Gene: 12458 Mouse
Entrez Gene: 308163 Rat
Omim: 601835 Human
SwissProt: P51684 Human
SwissProt: O54689 Mouse
Unigene: 46468 Human
Unigene: 8007 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CCR6/CD196也是是属于G蛋白偶联受体一家族成员，参与调节白细胞的迁移和活性作用，是细胞膜蛋白。

产品图片

Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-CCR6 Polyclonal Antibody, Unconjugated(HZ-1542R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining