ER-beta Antibody
产品名称: ER-beta Antibody
英文名称: ER-beta Antibody
产品编号: 250639
产品价格: null
产品产地: 美国
品牌商标: Abbiotec
更新时间: null
使用范围: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
深圳市豪地华拓生物科技有限公司
- 联系人 :
- 地址 : 深圳市南山创业路中兴城5栋518
- 邮编 : 518054
- 所在区域 : 广东
- 电话 : 132****4656 点击查看
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- 邮箱 : order@otwobiotech.com
Estrogen and progesterone receptors are members of a family transcription factors regulated by the binding of their cognate ligands. The interaction of hormone bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrogen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. Both have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B) which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors.