CHRDL1,脊索生成素样蛋白1抗体

产品编号HZ-11819R
英文名称CHRDL1
中文名称脊索生成素样蛋白1抗体
别 名CHL; chordin like 1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
CHRDL1,脊索生成素样蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CHRDL1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CHRDL1,脊索生成素样蛋白1抗体PubMedPubMed
产品介绍background:
The patterning of the central nervous system (CNS) relies on the interaction of multiple signaling molecules, including Shh (sonic hedgehog homolog), Wnt proteins and BMPs (bone morphogenetic proteins), with their antagonists, namely chordin and Noggin. Chordin is a key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like BMPs and sequestering them in latent complexes. CHRDL1 (Chordin-like protein 1), also known as CHL, VOPT (Ventroptin) or NRLN1 (Neuralin-1), is a 450 amino acid secreted protein that contains three VWFC domains. Functioning in a similar manner to chordin, CHRDL1 binds to BMP-4 and prevents the interaction of BMP-4 with its target receptors, thereby antagonizing BMP-4 activity. Additionally, CHRDL1 is thought to play a role in dorsoventral axis formation, embryonic bone formation and angiogenesis, as well as in the differentiation of neural stem cells.

Function:
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.

DISEASE:

CHRDL1,脊索生成素样蛋白1抗体Similarity:
Contains 3 VWFC domains.

Database links:
UniProtKB/Swiss-Prot: Q9BU40.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.