ADAMTS15,整合素样金属蛋白酶与凝血酶15型抗体

产品编号HZ-5857R
英文名称ADAMTS15
中文名称整合素样金属蛋白酶与凝血酶15型抗体
别 名A disintegrin and metalloproteinase with thrombospondin motifs 15; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15; A disintegrin like and metalloprotease Reprolysin type with thrombospondin type 1 motif 15 preproprotein; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 preproprotein; ADAM metallopeptidase with thrombospondin type 1 motif 15; ADAM TS 15; ADAM TS15; ADAMTS 15; ATS15_HUMAN.
规格价格0.1ml 0.2ml  
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 信号转导 细胞粘附分子
抗体来源Rabbit
克隆类型Polyclonal
ADAMTS15,整合素样金属蛋白酶与凝血酶15型抗体交叉反应Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量81kDa
细胞定位细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ADAMTS15
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ADAMTS15,整合素样金属蛋白酶与凝血酶15型抗体PubMedPubMed
产品介绍background:
ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.

Subcellular Location:
Secreted, extracellular space, extracellular matrix (By similarity).

Tissue Specificity:
Expressed in fetal liver and kidney, but not in any of the adult tissues examined.

Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity).
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).

Similarity:
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 3 TSP type-1 domains.

Database links:
UniProtKB/Swiss-Prot: Q8TE58.1

ADAMTS15,整合素样金属蛋白酶与凝血酶15型抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.