FITC标记的锌指蛋白423抗体
产品名称： FITC标记的锌指蛋白423抗体
英文名称： Anti-ZNF423/FITC
产品编号： HZ-12220R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ZNF423/FITC Conjugated antibody
FITC标记的锌指蛋白423抗体
| 英文名称 | Anti-ZNF423/FITC |
| 中文名称 | FITC标记的锌指蛋白423抗体 |
| 别 名 | Early B cell factor associated zinc finger protein; Ebfaz; hOAZ; Nur12; OAZ; OLF 1/EBF associated zinc finger; OLF1/EBF associated zinc finger protein; Olf1/EBF-associated zinc finger protein; Roaz; Smad and Olf interacting zinc finger protein; Smad- and Olf-interacting zinc finger protein; Zfp104; ZFP423; zinc finger protein 423, mouse, homolog of; Zinc finger protein 423; ZN423_HUMAN; ZNF423; ZNF423 zinc finger protein 423. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 转录调节因子 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Zebrafish, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 145kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human ZNF423/OAZ |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: OAZ is a 30-zinc finger, DNA-binding factor that associates with members of the Smad family of transcription factors in response to BMP2 activation. Bone morphogenic proteins (BMPs), are the largest group within the TGF Beta growth factors superfamily and are involved in embryonic development, specifically the formation of left-right asymmetry, neurogenesis, organogenesis and skeletal development. BMPs bind to surface receptors, which then phosphorylate serine residues of specific Smad proteins to induce Smad translocation to the nucleus and transcriptional activation of BMP targeted genes. OAZ specifically cooperates with the BMP-activated Smads, namely Smad1, 5 and 8, in binding to the CAGAC and TGGAGC boxes within the BRE, or BMP response element, and activating transcription. OAZ contains a BMP signaling module formed by two clusters of fingers that individually associate with either the Smads or the BMP response element. Distinct regions of OAZ, separate from the modules involved in BMP regulation, also enable OAZ to function as a transcriptional partner of Olf-1/EBF in olfactory epithelium and lymphocyte development, indicating that, as a multi–zinc finger protein, OAZ may have dual roles in signal transduction during development. Function: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Subunit: Homodimer (By similarity). Interacts with EBF1 (By similarity). Interacts with SMAD1 and SMAD4. Interacts with PARP1. Interacts with CEP290. Subcellular Location: Nucleus. Tissue Specificity: Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta. Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the adult brain, in the substantia nigra, medulla, amygdala, thalamus and cerebellum. DISEASE: Note=Defects in ZNF423 can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. ZNF423 mutations have been found in patients with nephronophthisis, cerebellar vermis hypoplasia and situs inversus, and Joubert syndrome. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 30 C2H2-type zinc fingers. Database links: Entrez Gene: 23090 Human Entrez Gene: 94187 Mouse Entrez Gene: 94188 Rat Entrez Gene: 566696 Zebrafish Omim: 604557 Human SwissProt: Q2M1K9 Human SwissProt: Q80TS5 Mouse SwissProt: O08961 Rat SwissProt: A1L1R6 Zebrafish Unigene: 530930 Human Unigene: 23452 Mouse Unigene: 472447 Mouse Unigene: 9981 Rat Unigene: 132594 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
OAZ是一种30锌指的DNA结合因子，与转录因子Smad家族的成员结合以响应BMP2的激活。骨形态发生蛋白（BMPs）是TGFβ生长因子超家族中最大的一类，参与胚胎发育，特别是左右不对称的形成、神经发生、器官发生和骨骼发育。BMP与表面受体结合，然后磷酸化特定Smad蛋白的丝氨酸残基以诱导Smad向细胞核的转移和BMP靶向基因的转录激活。OAZ与BMP激活的Smard（即Smad1、5和8）特别合作，与BRE内的CAGAC和TGGAGC盒或BMP响应元件结合，并激活转录。OAZ包含BMP信号模块，该模块由两个分别与Smads或BMP响应元素相关联的手指群组成。OAZ的独特区域，与BMP调节相关的模块分开，也使得OAZ在嗅上皮和淋巴细胞发育中能够作为Olf-1/EBF的转录伙伴发挥作用，表明OAZ作为一种多锌指蛋白，在信号转导中可能具有双重作用。在开发过程中。