FITC标记的TOX3蛋白抗体
产品名称： FITC标记的TOX3蛋白抗体
英文名称： Anti-TOX3/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TOX3/FITC Conjugated antibody
FITC标记的TOX3蛋白抗体
| 英文名称 | Anti-TOX3/FITC |
| 中文名称 | FITC标记的TOX3蛋白抗体 |
| 别 名 | BC052044; C230068E13; CAG trinucleotide repeat-containing gene F9 protein; CAGF9; TNRC9; TOX high mobility group box family member 3; TOX3; TOX3_HUMAN; Trinucleotide repeat containing 9; Trinucleotide repeat containing gene 9 protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 结合蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TOX3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | Function: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. Subunit: Homodimer. Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus) (By similarity). Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1 (phosphorylated form). Subcellular Location: Nucleus (Probable). Tissue Specificity: Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe. Similarity: Contains 1 HMG box DNA-binding domain. Database links: Entrez Gene: 27324 Human Entrez Gene: 244579 Mouse Entrez Gene: 291908 Rat Omim: 611416 Human SwissProt: O15405 Human SwissProt: Q80W03 Mouse SwissProt: B7SBD2 Rat Unigene: 460789 Human Unigene: 302755 Mouse Unigene: 41060 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
P300／CBP介导的转运复合物的转录共激活子通过cAMP应答元件（CRE）位点激活反式激活。通过诱导抗凋亡和抑制促凋亡基因转录来保护细胞死亡。刺激雌反应或Bcl-2启动子的转录。去极化诱导的神经元c-fos启动子转录激活所必需的。将染色质与雌应答的C3启动子区联系起来。