FITC标记的假定肿瘤抑制亮氨酸拉链蛋白1抗体
产品名称： FITC标记的假定肿瘤抑制亮氨酸拉链蛋白1抗体
英文名称： Anti-LZTS1/FITC
产品编号： HZ-5705R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-LZTS1/FITC Conjugated antibody
FITC标记的假定肿瘤抑制亮氨酸拉链蛋白1抗体
| 英文名称 | Anti-LZTS1/FITC |
| 中文名称 | FITC标记的假定肿瘤抑制亮氨酸拉链蛋白1抗体 |
| 别 名 | F37; F37/esophageal cancer related gene coding leucine zipper motif; Leucine zipper putative tumor suppressor 1; Psdzip70; LZTS1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LZTS1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq]. Function: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. Subunit: Binds EEF1G, TLK2 and CDK1. Subcellular Location: Cytoplasm (By similarity). Cell membrane (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). Tissue Specificity: Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines. Post-translational modifications: Phorphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression. DISEASE: Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease may be caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the LZTS family. Database links: UniProtKB/Swiss-Prot: Q9Y250.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码在正常组织中普遍表达的肿瘤抑制蛋白。在葡萄膜黑色素瘤中，这种蛋白在快速转移和转移的肿瘤细胞中沉默，但在缓慢转移或非转移的肿瘤细胞中具有正常表达。这种蛋白可能通过与CDK1/CyBurb1复合物相互作用在细胞周期调控中发挥作用。该基因位于染色体区域8p22。8P臂杂合性缺失（LOH）是许多类型癌症的共同特征。[由RefSeq提供]。