FITC标记的核转录因子抗体
产品名称： FITC标记的核转录因子抗体
英文名称： Anti-SOX1/FITC
产品编号： HZ-12276R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SOX1/FITC Conjugated antibody
FITC标记的核转录因子抗体
| 英文名称 | Anti-SOX1/FITC |
| 中文名称 | FITC标记的核转录因子抗体 |
| 别 名 | sex determining region Y box 1; sox1; SOX1_HUMAN; SRY; SOX-1; SRY box containing gene 1; SRY related HMG box gene 1; Transcription factor Sox-1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 神经生物学 干细胞 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Pig, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Human SOX6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Function: Transcriptional activator. Subcellular Location: Nucleus. Tissue Specificity: Mainly expressed in the developing central nervous system. Post-translational modifications: Sumoylation inhibits the transcriptional activity. Similarity: Contains 1 HMG box DNA-binding domain. Database links: Entrez Gene: 6656 Human Entrez Gene: 20664 Mouse Omim: 602148 Human SwissProt: O00570 Human SwissProt: P53783 Mouse Unigene: 202526 Human Unigene: 39088 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SOX基因包括与哺乳动物性别决定基因SRY相关的一系列基因。这些基因同样包含编码HMG-box结构域的序列，该结构域负责序列特异性DNA结合活性。Sox基因编码推测的转录调控因子，参与发育过程中细胞命运的决定以及不同发育过程的控制。高度复杂的SOX基因簇在不同的动物谱系中聚集至少40个不同的位点。目前已鉴定出30个SOX基因。这个家族的成员在进化过程中被证明是保守的，在动物的发展过程中起着关键的作用。有些人参与了人类疾病，包括性反转。