FITC标记的Homer蛋白抗体
产品名称： FITC标记的Homer蛋白抗体
英文名称： Anti-Homer/FITC
产品编号： HZ-17351R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Homer/FITC Conjugated antibody
FITC标记的Homer蛋白抗体
| 英文名称 | Anti-Homer/FITC |
| 中文名称 | FITC标记的Homer蛋白抗体 |
| 别 名 | HOME1_HUMAN; Homer; HOMER 1A; HOMER 1B; HOMER 1C; Homer protein homolog 1; Homer, neuronal immediate early gene, 1; Homer-1; Homer1; HOMER1A; HOMER1B; HOMER1C; SYN47; Ves 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 细胞膜受体 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Monkey, Xenopus laevis |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Homer |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008] Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Subunit: Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. {ECO:0000269|PubMed:10464340}. Subcellular Location: Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction; synapse. Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. Similarity: Belongs to the Homer family. Contains 1 WH1 domain. Database links: Entrez Gene: 9456 Human Entrez Gene: 26556 Mouse Entrez Gene: 29546 Rat Omim: 604798 Human SwissProt: Q86YM7 Human SwissProt: Q9Z2Y3 Mouse SwissProt: Q9Z214 Rat Unigene: 591761 Human Unigene: 37533 Mouse Unigene: 37500 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的HOME家族的树突状蛋白的成员。该家族成员调节第1组代谢型谷氨酸受体功能。[ RefSeq，JUL 2008 ]