FITC标记的肌球蛋白重链7抗体
产品名称： FITC标记的肌球蛋白重链7抗体
英文名称： Anti-MYH7B/FITC
产品编号： HZ-9862R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-MYH7B/FITC Conjugated antibody
FITC标记的肌球蛋白重链7抗体
| 产品编号 | bs-9862R-FITC |
| 英文名称 | Anti-MYH7B/FITC |
| 中文名称 | FITC标记的肌球蛋白重链7抗体 |
| 别 名 | adult 1; Beta myosin heavy chain; cardiac muscle beta isoform; CMD1S; CMH1; MPD1; MYH1; MYH1_HUMAN; MYH7; MYH7_HUMAN; Myhc slow; MyHC-2x; MyHC-beta; MyHC-IIx/d; MyHC-slow; MYHCB; Myopathy, distal 1; Myosin heavy chain (AA 1-96); Myosin heavy chain 1; Myosin heavy chain 2x; Myosin heavy chain 7; Myosin heavy chain; Myosin heavy chain IIx/d; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform; Myosin, heavy chain 7, cardiac muscle, beta; Myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-1; Myosin-7; Rhabdomyosarcoma antigen MU RMS 40.7A; skeletal muscle; SPMD. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 发育生物学 信号转导 干细胞 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 213kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MYH7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Myosin heavy chains are ubiquitous Actin-based motor proteins that convert the chemical energy derived from ATP hydrolysis into the mechanical energy that drives diverse motile processes in eukaryotic cells, including cytokinesis, vesicular transport and cellular locomotion. Muscle myosin is a heterohexamer consisting of two myosin heavy chains and two associated nonidentical pairs of myosin light chains. The seven myosin heavy chain isoforms that predominate in mammalian skeletal muscles include two developmental isoforms, MHC-embryonic (MYH3) and MHC-perinatal (MYH8); three adult skeletal muscle isoforms, MHC IIa (MYH2), MHC IIb (MYH4) and MHC IIx/d (MYH1); and MHC-∫/slow (MYH7 or MHC-∫), which is also expressed in cardiac muscle. Research indicates that mutations of the MYH7 gene causes hypertrophic cardiomyopathy. Function: Muscle contraction. Subunit: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Subcellular Location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. DISEASE: Defects in MYH7 are the cause of cardiomyopathy familial hypertrophic type 1 (CMH1) [MIM:192600]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYH7 are the cause of myopathy myosin storage (MYOMS) [MIM:608358]. In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers. Similarity: Contains 1 IQ domain. Contains 1 myosin head-like domain. Database links: Entrez Gene: 58498 Human Omim: 612147 Human SwissProt: Q01449 Human Unigene: 75636 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
肌球蛋白重链是普遍存在的肌动蛋白为基础的运动蛋白，将来自ATP水解的化学能转化为驱动真核细胞中各种运动过程的机械能，包括细胞分裂素、囊泡运输和细胞运动。肌肌球蛋白是由两个肌球蛋白重链和两个相关的非同一对肌球蛋白轻链组成的异倍体。在哺乳动物骨骼肌中占主导地位的七个肌球蛋白重链异构体包括两个发育亚型：MHC胚胎（MYH3）和MHC围产期（MYH8）；三个成年骨骼肌亚型、MHC IIA（MYH2）、MHC IIB（MYH4）和MHC IIX/D（MYH1）；以及MHC -γ/慢（MYH7或MHC--）、WHIC。H也在心肌中表达。研究表明，MYH7基因突变导致肥厚型心肌病。