FITC标记的钙激活蛋白酶12抗体
产品名称： FITC标记的钙激活蛋白酶12抗体
英文名称： Anti-Calpain 12/FITC
产品编号： HZ-6798R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Calpain 12/FITC Conjugated antibody
FITC标记的钙激活蛋白酶12抗体
| 英文名称 | Anti-Calpain 12/FITC |
| 中文名称 | FITC标记的钙激活蛋白酶12抗体 |
| 别 名 | Calpain12; Calpain-12; CAPN 12; CAPN12; EC 3.4.22.; MGC20576; CAN12_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 81kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Calpain 12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Calpains are a family of cytosolic calcium activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin and cytoskeletal interactions, and synaptic plasticity. Calpain 12 was first described in the mouse, most strongly in the skin, and maps to mouse chromosome 7. Isoforms differ in the carboxyterminal ends, ending with aberrant domain III and lacking domain IV. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV, making Calpain 12 most similar to calpains 1 and 2. Function: Calcium-regulated non-lysosomal thiol-protease (By similarity). Similarity: Belongs to the peptidase C2 family. Contains 1 calpain catalytic domain. Contains 1 EF-hand domain. Database links: Entrez Gene: 147968 Human Entrez Gene: 60594 Mouse Entrez Gene: 308476 Rat Omim: 608839 Human SwissProt: Q6ZSI9 Human SwissProt: Q9ER56 Mouse Unigene: 731775 Human Unigene: 476990 Mouse Unigene: 219171 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CalP痛是一类细胞内钙激活的半胱氨酸蛋白酶，参与多种细胞过程，包括细胞凋亡、细胞分裂、整合素和细胞骨架相互作用的调节以及突触可塑性。钙蛋白酶12首先在小鼠中被描述，最强烈地在皮肤中，并且映射到小鼠染色体7。异构体在羧基末端不同，终止于异常结构域III和缺乏结构域IV。在大亚基中的结构域包括氨基末端结构域I、蛋白酶结构域II、结构域III和EF手域IV，使得钙蛋白酶12最类似于CalP痛1和2。