FITC标记的G蛋白偶联嘌呤受体p2y6抗体
产品名称： FITC标记的G蛋白偶联嘌呤受体p2y6抗体
英文名称： Anti-P2Y6/FITC
产品编号： HZ-12075R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-P2Y6/FITC Conjugated antibody
FITC标记的G蛋白偶联嘌呤受体p2y6抗体
| 英文名称 | Anti-P2Y6/FITC |
| 中文名称 | FITC标记的G蛋白偶联嘌呤受体p2y6抗体 |
| 别 名 | G coupled nucleotide receptor; G protein coupled 6; MGC15335; P2 purinoceptor; P2RY6; P2RY6_HUMAN; P2Y purinoceptor 6; P2Y6; P2Y6 receptor; PP2891; Purinergic receptor P2Y6; pyrimidinergic receptor P2Y; Pyrimidinergic receptor P2Y, G protein coupled, 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 通道蛋白 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human P2Y6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Nucleotides are emerging as important extracellular signaling molecules that mediate several effects, such as proliferation, differentiation, chemotaxis and cytokine release. The P2 receptor family is activated by the binding of nucleotides and is divided into two subfamilies, P2X and P2Y. The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The P2Y receptor family are G protein-coupled receptors which mediate the effects of extracellular nucleotides, primarily through the activation of phospholipase C. To some extent, the P2Y receptors can also activate potassium channels or, alternatively, inhibit adenylate cyclase and N-type calcium channels in response to extracellular nucleotides. The P2Y receptors are differentially expressed in several tissue types, such as heart, lung and brain. However, all P2Y receptors are expressed in leukocytes, which suggests a role for the P2Y receptor family in the activation of leukocytes and platelets in response to inflammation or vascular damage. Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 539703 Cow Entrez Gene: 485202 Dog Entrez Gene: 5031 Human Entrez Gene: 100512849 Pig Omim: 602451 Human SwissProt: Q15077 Human Unigene: 16362 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
核苷酸是重要的细胞外信号分子，介导多种效应，如增殖、分化、趋化和细胞因子释放。P2受体家族通过核苷酸的结合而被激活，并被分为两个亚家族，P2X和P2Y。P2X受体家族包括配体门控离子通道，其允许细胞外钙ATP反应增加钙进入细胞的渗透性。2Y受体家族是G蛋白偶联受体，介导胞外核苷酸的作用，主要是通过激活磷脂酶C。在一定程度上，p2Y受体也可以激活钾通道，或者选择性地抑制腺苷酸环化酶和N型钙。对细胞外核苷酸反应的通道。2Y受体在多种组织类型中有差异表达，如心脏、肺和脑。然而，所有的2Y受体在白细胞中表达，这提示了在炎症或血管损伤中白细胞和血小板活化中的PY受体家族的作用。