FITC标记的溶血磷脂酸受体蛋白1/EDG2抗体
产品名称： FITC标记的溶血磷脂酸受体蛋白1/EDG2抗体
英文名称： Anti-LPA1/FITC
产品编号： HZ-2880R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LPA1/FITC Conjugated antibody
FITC标记的溶血磷脂酸受体蛋白1/EDG2抗体
| 英文名称 | Anti-LPA1/FITC |
| 中文名称 | FITC标记的溶血磷脂酸受体蛋白1/EDG2抗体 |
| 别 名 | EDG 2; Endothelial Cell Differentiation Gene-2; Endothelial differentiation gene 2; Endothelial Differentiation Lysophosphatidic Acid G Protein Coupled Receptor 2; G10 protein homolog; GPCR 26; GPCR26; Gpcr91; Kdt2; LPA 1; LPA receptor 1; LPA receptor EDG2; LPA1; LPAR1; Lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor EDG2; MGC105279; MGC29102; LPAR1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 G蛋白偶联受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EDG2/LPA1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several proteins not used within 12 hours. Edg2 has been reported in most human tissues, and is especially abundant in brain cortical regions. ESTs have been isolated from bone, brain, breast, connective tissue, embryo, heart/melanocyte/uterus, lung, prostate and uterus libraries. Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Subunit: Interacts with RALA and ADRBK1. Subcellular Location: Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles. Tissue Specificity: Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 281136 Cow Entrez Gene: 1902 Human Entrez Gene: 14745 Mouse Entrez Gene: 116744 Rat Omim: 602282 Human SwissProt: Q28031 Cow SwissProt: Q92633 Human SwissProt: P61793 Mouse SwissProt: P61794 Rat SwissProt: P46628 Sheep Unigene: 126667 Human Unigene: 4772 Mouse Unigene: 11200 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
EDG2属于G-蛋白偶联受体家族，其配体为溶血磷脂。EDG受体家族有八个已知成员，它们参与介导与生长相关的效应，如诱导细胞增殖、分化和存活的改变以及抑制细胞凋亡。他们也唤起细胞效应功能，依赖于细胞骨架反应，如收缩，分泌，粘附和趋化。EDG受体是发育调节和不同的组织分布。它们与多种类型的G蛋白偶联，通过RAS和MAP激酶、Rho、磷脂酶C和12小时内未使用的几种蛋白质进行信号传递。EDG2在大多数人类组织中已有报道，在脑皮质区尤为丰富。EST已从骨、脑、乳腺、结缔组织、胚胎、心脏/黑素细胞/子宫、肺、前列腺和子宫库中分离出来。