FITC标记的RSC1A1蛋白抗体
产品名称： FITC标记的RSC1A1蛋白抗体
英文名称： Anti-RSC1A1/FITC
产品编号： HZ-18866R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-RSC1A1/FITC Conjugated antibody
FITC标记的RSC1A1蛋白抗体
| 英文名称 | Anti-RSC1A1/FITC |
| 中文名称 | FITC标记的RSC1A1蛋白抗体 |
| 别 名 | Regulator Of Solute Carriers 1; Regulatory Solute Carrier Protein, Family 1, Member 1; Transporter Regulator RS1; Regulatory Solute Carrier Protein Family 1 Member 1; HRS1; RS1; RSCA1_HUMAN; |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 68kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RSC1A1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: RSC1A1 is 617 amino acid nuclear protein that localizes to the inner side of the plasma membrane and the Golgi apparatus. Expressed in small intestine, kidney and brain, RSC1A1 mediates transcriptional and post-transcriptional regulation of Na(+)-D-glucose cotransporter SGLT-1 (sodium/glucose cotransporter 1). RSC1A1 is thought to inhibit the dynamin-dependent release of SGLT-1-containing vesicles from the TGN (trans-Golgi network). Mutations in the gene encoding RSC1A1 may lead to leptin-independent up-regulation of food intake, which is suggested to be partially responsible for obesity. The gene encoding is RSC1A1 located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Function: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity). Regulates the expression of SLC5A1 in a tissue-specific manner and is specifically involved in its regulation in the small intestine. Subunit: Interacts with YRDC. Subcellular Location: Cell Membrane, Golgi Apparatus and Nuclear. Tissue Specificity: Expressed in epithelial and subepithelial cells of small intestine. Database links:
Entrez Gene: 6248 Human Entrez Gene: 69994 Mouse Omim: 601966 Human SwissProt: Q92681 Human SwissProt: Q9ER99 Mouse Unigene: 657818 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
RSC1A1是定位于质膜和高尔基体的内侧的617个氨基酸的核蛋白。在小肠中表达，肾、脑、rsc1a1介导转录和转录后调节的Na（+）-葡萄糖共转运体SGLT-1（钠/葡萄糖协同转运蛋白1）。RSC1A1被认为抑制来自TGN（跨高尔基网络）的SGLT-1含有囊泡的依赖于动力的释放。在编码rsc1a1基因突变可导致瘦素独立的调节食物摄入量，这可能是肥胖的部分原因。是rsc1a1编码基因位于人类1号染色体上，它跨越了2亿6000万个碱基对，包含超过3000个基因，包括近8%的人类基因组