Flightless 1,凝溶胶蛋白家族Fli-1/Flightless I抗体

产品编号HZ-7864R
英文名称Flightless 1
中文名称凝溶胶蛋白家族Fli-1/Flightless I抗体
别 名Fli 1; FLI; Fli1; Flightless-1; Flightless1; Flightless 1; Flightless I (Drosophila) homolog; Flightless I homolog; Flightless I homolog (Drosophila); Flightless1; FlightlessI; FLII; Fliih; FLIL; MGC39265; Protein flightless 1 homolog; FLI1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 干细胞 细胞周期蛋白 细胞分化 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
Flightless 1,凝溶胶蛋白家族Fli-1/Flightless I抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Flightless 1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Flightless 1,凝溶胶蛋白家族Fli-1/Flightless I抗体PubMedPubMed
产品介绍background:
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene leads to abnormal muscle function, arrested development and embryonic lethality. The protein sequence shows that this might be a regulator of cytoskeleton and may have a role during cell division.

Function:
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Subunit:
Can form homodimers or heterodimers with ETV6/TEL1.

Subcellular Location:
Nucleus.

Flightless 1,凝溶胶蛋白家族Fli-1/Flightless I抗体DISEASE:
Defects in FLI1 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.

Similarity:
Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.

Database links:
Entrez Gene: 2314 Human
Entrez Gene: 14248 Mouse
Entrez Gene: 287375 Rat
Omim: 600362 Human
SwissProt: Q13045 Human
SwissProt: Q9JJ28 Mouse
Unigene: 513984 Human
Unigene: 339755 Mouse
Unigene: 144698 Rat

Flightless 1,凝溶胶蛋白家族Fli-1/Flightless I抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.