FITC标记的NLRP8蛋白抗体
产品名称： FITC标记的NLRP8蛋白抗体
英文名称： Anti-NLRP8/FITC
产品编号： HZ-19287R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NLRP8/FITC Conjugated antibody
FITC标记的NLRP8蛋白抗体
| 英文名称 | Anti-NLRP8/FITC |
| 中文名称 | FITC标记的NLRP8蛋白抗体 |
| 别 名 | CLR19.2; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 8; NACHT, leucine rich repeat and PYD containing 8; NACHT, LRR and PYD containing protein 8; NACHT, LRR and PYD domains-containing protein 8; NALP8; NALP8_HUMAN; NLR family, pyrin domain containing 8; NLRP8; NOD16; Nucleotide-binding oligomerization domain protein 16; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8; PAN4; PYRIN and NACHT-containing protein 4; PYRIN domain- and NACHT domain-containing protein 4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞凋亡 结合蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 119kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NLRP8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008] Function: Involved in inflammation. Subcellular Location: Cytoplasm. Similarity: Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 5 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Database links: Entrez Gene: 126205 Human Omim: 609659 Human SwissProt: Q86W28 Human Unigene: 446925 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
NALPS是细胞质蛋白，在较大的卡特彼勒蛋白家族中形成亚家族。大多数短的NALP，如NALP8，具有N-末端pyrin(MEFV；MIM 608107)结构域(PYD)，随后是NACHT结构域、NACHT相关结构域(NAD)和C-末端富含亮氨酸重复序列(LRR)区域。长NALP，NALP1（MIM 606636），还具有C端扩展，包含查找域（FIIND）和caspase招聘域（CARD）的功能。NALP通过参与被称为炎症小体的多蛋白复合物而参与促炎性caspases(例如，CASP1；MIM 147678)的激活(Tschopp等人，2003[PubMed 12563287])。