FITC标记的磷酸化腺苷单磷酸活化蛋白激酶β1抗体
产品名称： FITC标记的磷酸化腺苷单磷酸活化蛋白激酶β1抗体
英文名称： Anti-phospho-AMPK beta 1 (Ser108)/FITC
产品编号： HZ-3026R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-AMPK beta 1 (Ser108)/FITC Conjugated antibody
FITC标记的磷酸化腺苷单磷酸活化蛋白激酶β1抗体
| 英文名称 | Anti-phospho-AMPK beta 1 (Ser108)/FITC |
| 中文名称 | FITC标记的磷酸化腺苷单磷酸活化蛋白激酶β1抗体 |
| 别 名 | PRKAB1(phospho S108); PRKAB1(phospho-S108); AMPK beta 1(Ser108); p-AMPK beta 1(Ser108); p-AMPK beta 1(S108); 5 AMP activated protein kinase subunit beta 1; AMPK; AMPK beta 1 chain; AMPKb; HAMPKb; PRKAB1; 5'-AMP-activated protein kinase subunit beta-1; AMP-activated protein kinase beta subunit; protein kinase, AMP-activated, noncatalytic, beta-1; AMPK beta -1 chain; 5'-AMP-activated protein kinase beta-1 subunit; AMPKb; AMPK subunit beta-1; AAKB1_RAT; AAKB1_HUMAN; AMPK b1; AMPK-b1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from rat AMPK beta 1 around the phosphorylation site of Ser108 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]. Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). Subunit: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Tissue Specificity: Highly expressed in kidney, heart, white adipose tissue, lung and spleen. Post-translational modifications: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. Similarity: Belongs to the 5'-AMP-activated protein kinase beta subunit family. Database links:
Entrez Gene: 5564 Human Entrez Gene: 19079 Mouse Entrez Gene: 83803 Rat Omim: 602740 Human SwissProt: Q9Y478 Human SwissProt: Q9R078 Mouse SwissProt: P80386 Rat Unigene: 6061 Human Unigene: 726001 Human Unigene: 458152 Mouse Unigene: 3619 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. AMPKβ1(AMP-activated Protein Kinase beta-1)(腺苷单磷酸活化蛋白激酶β-1)是一种参与细胞适应能量危机的应激反应酶,AMPK不仅可以在细胞水平作为能量的感受器，还可以通过激素和细胞因子，如瘦素、脂联素和ghrelin来参与调节机体的能量消耗和能量摄 |
由该基因编码的蛋白质是AMP活化蛋白激酶（AMPK）的调节亚基。AMPK是由α催化亚基和非催化β和γ亚基组成的异三聚体。AMPK是监测细胞能量状态的重要能量传感酶。响应于细胞代谢应激，AMPK被激活，并因此磷酸化和失活acetyl CoA carboxylase（ACC）和β-羟基β-甲基戊二酸CoA reductase（HMGCR），参与调节脂肪酸和胆固醇从头合成的关键酶。该亚基可能是AMPK活性的正调控因子。该亚单位的肉豆蔻酰化和磷酸化已被证明影响AMPK的酶活性和细胞定位。该亚基还可以作为介导AMPK复合物的缔合分子的适配器分子。[ RefSeq，JUL 2008 ]提供。