IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulates secretion of IL-8, and induces activation of the transcription factor NF-κB in cells that express the IL-17BR receptor.
The BioGems Human IL-17E/IL-25 Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure Human IL-17E/IL-25 with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for IL-17E/IL-25. It contains E. coli-expressed recombinant Human IL-17E/IL-25. The detection antibody is a biotinylated goat polyclonal antibody specific for IL-17E/IL-25. The kit is analytically validated with ready to use reagents.